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# Targeted therapy - The Evidence Ledger

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### [Targeted therapy](/c/targeted-therapy)

MechanismESTABLISHEDOutcomeA

Claimed

Drugs aimed at a tumor's specific mutation.

What holds up

Mutation-specific drug design, one of the two biggest advances of the last 15 years.

What it does not show

For a patient whose tumor has the matching mutation, often the best option that exists.

Evidence for

None on file.

Sources

No sources on file yet.

## Grade history (append-only)

Every grade change is kept, never overwritten, so the current grade and every prior one stay visible.

Mechanism gradeJustificationGraded byStateGraded at

ESTABLISHEDMutation-specific drug design, one of the two biggest advances of the last 15 years.seeddisplayed2026-09-03T21:29:06.052Z

Outcome gradeJustificationGraded byStateGraded at

AFor a patient whose tumor has the matching mutation, often the best option that exists.seeddisplayed2026-09-03T21:29:06.053Z

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