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# Ivermectin - The Evidence Ledger

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### [Ivermectin](/c/ivermectin)

MechanismPLAUSIBLEOutcomeD

Claimed

A Nobel-winning anti-parasitic that hits tubulin, mitochondria, p53 and HIF-1 in cancer cells, and, combined with a benzimidazole, 'attacks cancer twenty ways.'

What holds up

Broad preclinical literature across cancer types, including sensitizing lung cancer cells to paclitaxel.

What it does not show

Only human outcome study is uncontrolled, unblinded, self-reported, and authored by the protocol's advocates.

Evidence for

Hulscher, Marik, Makis et al., Anticancer Research 2026;46(6):3243, PMID 42203321, Rockwell et al., JAMA Network Open 2026;9(5):e2616780 (demand study, not efficacy), Sulik et al., Eur J Med Chem Reports 2024, Hayashi et al., Anticancer Research 2024;44(12):5271

Sources

VERIFIED Hulscher, Marik, Makis et al., Anticancer Research 2026;46(6):3243, PMID 42203321. VERIFIED Rockwell et al., JAMA Network Open 2026;9(5):e2616780 (demand study, not efficacy). VERIFIED Sulik et al., Eur J Med Chem Reports 2024. VERIFIED Hayashi et al., Anticancer Research 2024;44(12):5271. VERIFIED Factually / The Conversation evidence review, May 2026.

## Grade history (append-only)

Every grade change is kept, never overwritten, so the current grade and every prior one stay visible.

Mechanism gradeJustificationGraded byStateGraded at

PLAUSIBLEBroad preclinical literature across cancer types, including sensitizing lung cancer cells to paclitaxel.seeddisplayed2026-09-03T21:29:06.030Z

Outcome gradeJustificationGraded byStateGraded at

DOnly human outcome study is uncontrolled, unblinded, self-reported, and authored by the protocol's advocates.seeddisplayed2026-09-03T21:29:06.030Z

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