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# Immunotherapy - The Evidence Ledger

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### [Immunotherapy](/c/immunotherapy)

MechanismESTABLISHEDOutcomeA

Claimed

Checkpoint inhibitors and related drugs that unleash the immune system against tumors.

What holds up

Checkpoint biology (PD-1/PD-L1, CTLA-4) is well characterized.

What it does not show

Turned some metastatic melanomas and lung cancers from fatal into long-term survivable. Works spectacularly for some, not at all for others.

Evidence for

None on file.

Sources

No sources on file yet.

## Grade history (append-only)

Every grade change is kept, never overwritten, so the current grade and every prior one stay visible.

Mechanism gradeJustificationGraded byStateGraded at

ESTABLISHEDCheckpoint biology (PD-1/PD-L1, CTLA-4) is well characterized.seeddisplayed2026-09-03T21:29:06.051Z

Outcome gradeJustificationGraded byStateGraded at

ATurned some metastatic melanomas and lung cancers from fatal into long-term survivable. Works spectacularly for some, not at all for others.seeddisplayed2026-09-03T21:29:06.052Z

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