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Heat: hyperthermia

MechanismESTABLISHEDOutcomeB (with radiation)
Claimed

Heating a tumor to around 40 to 43 degrees Celsius weakens cancer cells and makes radiation and some chemotherapy work better.

What holds up

Tumor brought to measured temperature; standard in some European centers.

What it does not show

Randomized trials in cervical cancer (Dutch Deep Hyperthermia Trial) and sarcoma (EORTC).

Evidence for

van der Zee et al., Lancet 2000, Issels et al., Lancet Oncology 2010 and JAMA Oncology 2018 follow-up

Sources

PENDING van der Zee et al., Lancet 2000. PENDING Issels et al., Lancet Oncology 2010 and JAMA Oncology 2018 follow-up.

Grade history (append-only)

Every grade change is kept, never overwritten, so the current grade and every prior one stay visible.

Mechanism gradeJustificationGraded byStateGraded at
ESTABLISHEDTumor brought to measured temperature; standard in some European centers.seeddisplayed2026-09-03T21:29:06.038Z
Outcome gradeJustificationGraded byStateGraded at
B (with radiation)Randomized trials in cervical cancer (Dutch Deep Hyperthermia Trial) and sarcoma (EORTC).seeddisplayed2026-09-03T21:29:06.038Z

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